SrasV1, Main, Exploration, bibRecord, 001F86

Evidence for ACE2-Utilizing Coronaviruses (CoVs) Related to Severe Acute Respiratory Syndrome CoV in Bats

Identifieur interne : 001F86 ( Main/Exploration ); précédent : 001F85; suivant : 001F87

Evidence for ACE2-Utilizing Coronaviruses (CoVs) Related to Severe Acute Respiratory Syndrome CoV in Bats

Auteurs : Ann Demogines [États-Unis] ; Michael Farzan [États-Unis] ; Sara L. Sawyer [États-Unis]

Source :

Journal of virology [ 0022-538X ] ; 2012.

RBID : Pascal:12-0227829

Descripteurs français

KwdFr :
- Animaux, Chiroptera (virologie), Humains, Modèles moléculaires, Peptidyl-Dipeptidase A (génétique), Peptidyl-Dipeptidase A (métabolisme), Pénétration virale, Récepteurs viraux (génétique), Récepteurs viraux (métabolisme), Sélection génétique, Virus du SRAS (génétique), Virus du SRAS (physiologie).
MESH :
- génétique : Peptidyl-Dipeptidase A, Récepteurs viraux, Virus du SRAS.
- métabolisme : Peptidyl-Dipeptidase A, Récepteurs viraux.
- physiologie : Virus du SRAS.
- virologie : Chiroptera.
Pascal (Inist)
- Animaux, Humains, Modèles moléculaires, Pénétration virale, Syndrome respiratoire aigu sévère, Sélection génétique.

English descriptors

KwdEn :
- Animals, Chiroptera (virology), Humans, Models, Molecular, Peptidyl-Dipeptidase A (genetics), Peptidyl-Dipeptidase A (metabolism), Receptors, Virus (genetics), Receptors, Virus (metabolism), SARS Virus (genetics), SARS Virus (physiology), Selection, Genetic, Severe acute respiratory syndrome, Virus Internalization.
MESH :
- chemical , genetics : Peptidyl-Dipeptidase A, Receptors, Virus.
- chemical , metabolism : Peptidyl-Dipeptidase A, Receptors, Virus.
- genetics : SARS Virus.
- physiology : SARS Virus.
- virology : Chiroptera.
- Animals, Humans, Models, Molecular, Selection, Genetic, Virus Internalization.

Abstract

In 2002, severe acute respiratory syndrome (SARS)-coronavirus (CoV) appeared as a novel human virus with high similarity to bat coronaviruses. However, while SARS-CoV uses the human angiotensin-converting enzyme 2 (ACE2) receptor for cellular entry, no coronavirus isolated from bats appears to use ACE2. Here we show that signatures of recurrent positive selection in the bat ACE2 gene map almost perfectly to known SARS-CoV interaction surfaces. Our data indicate that ACE2 utilization preceded the emergence of SARS-CoV-like viruses from bats.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372174

Affiliations:

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<front><div type="abstract" xml:lang="en">In 2002, severe acute respiratory syndrome (SARS)-coronavirus (CoV) appeared as a novel human virus with high similarity to bat coronaviruses. However, while SARS-CoV uses the human angiotensin-converting enzyme 2 (ACE2) receptor for cellular entry, no coronavirus isolated from bats appears to use ACE2. Here we show that signatures of recurrent positive selection in the bat ACE2 gene map almost perfectly to known SARS-CoV interaction surfaces. Our data indicate that ACE2 utilization preceded the emergence of SARS-CoV-like viruses from bats.</div>
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Evidence for ACE2-Utilizing Coronaviruses (CoVs) Related to Severe Acute Respiratory Syndrome CoV in Bats

Evidence for ACE2-Utilizing Coronaviruses (CoVs) Related to Severe Acute Respiratory Syndrome CoV in Bats

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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